Description

2-(4-Methylpiperazin-1-Yl)-5-Nitrobenzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its distinct nitrile and nitro-substituted aromatic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting kinase inhibition.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Used in the controlled synthesis of complex molecules where the introduction of a methylpiperazine moiety is required.
• Biochemical Tool Compound: May be utilized in the development of assay probes and biochemical tools for target validation studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	2-(4-Methylpiperazin-1-Yl)-5-Nitrobenzonitrile
CAS No.	451459-92-0
Molecular Formula	C13H16N4O2
Molecular Weight	260.30 g/mol
Synonyms	5-Nitro-2-(4-methyl-1-piperazinyl)benzonitrile; 2-(4-Methyl-1-piperazinyl)-5-nitrobenzonitrile; Benzonitrile, 2-(4-methyl-1-piperazinyl)-5-nitro-; 451459-92-0; 2-(4-Methylpiperazin-1-yl)-5-nitrobenzonitrile; 5-Nitro-2-(4-methylpiperazin-1-yl)benzonitrile
EINECS	Contact for details

Quality Control

Our 2-(4-Methylpiperazin-1-Yl)-5-Nitrobenzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with cGMP standards for advanced clinical trials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.