Description

4H-Pyrazolo[3,4-D]Pyrimidin-4-One, 5-(4-Ethylphenyl)-1,5-Dihydro-6-[[(2-Methylphenyl)Methyl]Thio]- is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidinone class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key synthetic building block in the development of novel therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of targeted kinase inhibitors and other small molecule drug candidates.
• Biochemical Research: Used as a reference standard or a probe compound in enzymatic assays and biological pathway studies.
• Medicinal Chemistry R&D: Employed in structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and pharmacokinetic properties.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	4H-Pyrazolo[3,4-D]Pyrimidin-4-One, 5-(4-Ethylphenyl)-1,5-Dihydro-6-[[(2-Methylphenyl)Methyl]Thio]-
CAS No.	451458-32-5
Molecular Formula	C21H20N4OS
Molecular Weight	376.48 g/mol
Synonyms	5-(4-Ethylphenyl)-6-[(2-methylbenzyl)thio]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; 6-[(2-Methylbenzyl)thio]-5-(4-ethylphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; 451458-32-5; 5-(4-Ethylphenyl)-1,5-dihydro-6-[[(2-methylphenyl)methyl]thio]-4H-pyrazolo[3,4-d]pyrimidin-4-one; Pyrazolo[3,4-d]pyrimidin-4-one derivative
EINECS	Contact for details

Quality Control

Our 4H-Pyrazolo[3,4-D]Pyrimidin-4-One intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.