Description

Pamapimod CAS NO 449811-01-2 is a potent and selective small-molecule inhibitor targeting p38 mitogen-activated protein kinase (MAPK) alpha. This compound is crucial for pharmaceutical research and development, particularly in studying inflammatory signaling pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery for autoimmune diseases, inflammatory disorders, and oncology.

Application

• Pharmaceutical Research: Serves as a key biochemical tool for investigating the role of p38α MAPK in cellular signaling cascades related to inflammation and stress response.
• Drug Discovery & Development: Used as a reference standard or lead compound in the development of novel anti-inflammatory and immunomodulatory therapeutics.
• Preclinical Studies: Employed in in vitro and in vivo models to validate p38α as a therapeutic target and to assess the efficacy of potential drug candidates.
• Biochemical Assays: Acts as a specific inhibitor in high-throughput screening (HTS) and enzyme activity assays to study kinase function and inhibitor potency.
• Academic Research: Supports fundamental research in molecular biology, immunology, and cell signaling pathways at universities and research institutes.

Basic Information

Product Name	Pamapimod
CAS No.	449811-01-2
Molecular Formula	C₂₀H₂₀N₄O₂
Molecular Weight	348.40 g/mol
Synonyms	Pamapimod; RO4402257; 6-(2,4-Difluorophenoxy)-2-[(3S)-3-(methylamino)-1-pyrrolidinyl]-4-pyrimidinecarboxamide; 6-(2,4-Difluorophenoxy)-2-[(3S)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-4-carboxamide; UNII-2K5P6BQG9I; p38 MAPK inhibitor; p38 alpha inhibitor
EINECS	Contact for details

Quality Control

Our Pamapimod is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.