Description

1-(2-Carboxyphenyl)-Piperazine is a high-purity, functionalized piperazine derivative of significant interest in advanced organic synthesis. This compound matters as a versatile and critical building block for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), fine chemicals, and novel material science applications.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides, fungicides, and plant growth regulators requiring specific piperazine-based scaffolds.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functional polymers, dyes, and advanced organic materials with tailored properties.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new chemical reactions in laboratory-scale research.
• Custom Synthesis & Contract Manufacturing: Supplied as a starting material for bespoke synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	1-(2-Carboxyphenyl)-Piperazine
CAS No.	446831-27-2
Molecular Formula	C11H14N2O2
Molecular Weight	206.24 g/mol
Synonyms	2-(Piperazin-1-yl)benzoic acid; 1-(2-Carboxyphenyl)piperazine; 2-Piperazin-1-ylbenzoic acid; Benzoic acid, 2-(1-piperazinyl)-; Piperazine, 1-(2-carboxyphenyl)-; (2-Piperazin-1-ylphenyl)methanol (oxidized form reference); o-(Piperazin-1-yl)benzoic acid
EINECS	Contact for details

Quality Control

Our 1-(2-Carboxyphenyl)-Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets stringent specifications for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.