Description

2-(4-Boc-Piperazinyl)-2-(2-Methylphenyl)Acetic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazine moiety and a chiral acetic acid derivative. This compound is critical for medicinal chemists as a versatile building block in the synthesis of complex, biologically active molecules, particularly for central nervous system (CNS) and oncology targets. It is primarily utilized by research institutions, contract research organizations (CROs), and active pharmaceutical ingredient (API) manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting G-protein-coupled receptors (GPCRs).
• Protease Inhibitor Development: Used in the research and construction of molecules designed to inhibit specific enzymes involved in disease pathways.
• Peptidomimetic Chemistry: Serves as a crucial component for creating non-peptide compounds that mimic the structure and function of peptides.
• Library Synthesis for High-Throughput Screening (HTS): Employed to generate diverse compound libraries to identify new lead structures in drug discovery programs.
• API Process Development & Scale-Up: Integral in the route scouting and optimization phases for the commercial manufacturing of new chemical entities (NCEs).
• Academic & Institutional Research: Used in fundamental chemical and pharmacological research exploring new synthetic methodologies and structure-activity relationships (SAR).

Basic Information

Product Name	2-(4-Boc-Piperazinyl)-2-(2-Methylphenyl)Acetic Acid
CAS No.	444893-65-6
Molecular Formula	C18H26N2O4
Molecular Weight	334.41 g/mol
Synonyms	2-(4-[(tert-Butoxy)carbonyl]piperazin-1-yl)-2-(2-methylphenyl)acetic acid; 2-(2-Methylphenyl)-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]acetic acid; 2-(4-Boc-1-piperazinyl)-2-(o-tolyl)acetic acid; Boc-Pip-o-Tol-Gly-OH; (2-Methylphenyl)[4-(tert-butoxycarbonyl)piperazin-1-yl]acetic acid; N-Boc-4-(2-(2-methylphenyl)-2-oxoethyl)piperazine; 444893-65-6
EINECS	Contact for details

Quality Control

Our 2-(4-Boc-Piperazinyl)-2-(2-Methylphenyl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with stringent specifications for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.