Description

1-Boc-4-(2-Amino-1-(4-Methoxy-Phenyl)Ethyl)-Piperazine is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile, reactive amine handle for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), especially within the CNS and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting neurological disorders and cancer.
• Peptidomimetic Chemistry: Used to introduce constrained piperazine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand Synthesis for Drug Discovery: Employed in the construction of complex molecular libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Serves as a building block for creating labeled compounds and probes used to study biological pathways and target engagement.
• Process Chemistry Development: Utilized in route scouting and optimization for the scalable manufacturing of target molecules under GMP-like conditions.
• Academic & Contract Research: A valuable reagent for universities and CROs conducting cutting-edge research in synthetic methodology and medicinal chemistry.

Basic Information

Product Name	1-Boc-4-(2-Amino-1-(4-Methoxy-Phenyl)Ethyl)-Piperazine
CAS No.	444892-61-9
Molecular Formula	C18H29N3O3
Molecular Weight	335.44 g/mol
Synonyms	1-Boc-4-[2-Amino-1-(4-methoxyphenyl)ethyl]piperazine; tert-Butyl 4-[2-amino-1-(4-methoxyphenyl)ethyl]piperazine-1-carboxylate; 4-(2-Amino-1-(4-methoxyphenyl)ethyl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-4-(2-amino-1-(4-methoxyphenyl)ethyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(2-amino-1-(4-methoxyphenyl)ethyl)piperazine; Piperazine, 1-(1,1-dimethylethoxy)carbonyl-4-[2-amino-1-(4-methoxyphenyl)ethyl]-
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(2-Amino-1-(4-Methoxy-Phenyl)Ethyl)-Piperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.