Description

tert-Butyl 4-(3-Bromo-5-(Trifluoromethyl)Phenyl)Piperazine-1-Carboxylate is a high-value, multi-functional piperazine derivative and a crucial advanced pharmaceutical intermediate. Its molecular architecture, featuring a bromo-substituted trifluoromethylphenyl group, makes it an essential building block for synthesizing complex bioactive molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) agents, kinase inhibitors, and other receptor-targeted therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl and bromo groups contribute to biological activity and metabolic stability.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Ligand and Catalyst Preparation: The piperazine nitrogen atoms can be functionalized to create novel ligands for catalysis or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing tailored compounds for client projects.

Basic Information

Product Name	tert-Butyl 4-(3-Bromo-5-(Trifluoromethyl)Phenyl)Piperazine-1-Carboxylate
CAS No.	444727-13-3
Molecular Formula	C16H20BrF3N2O2
Molecular Weight	409.25 g/mol
Synonyms	1-Boc-4-(3-Bromo-5-(trifluoromethyl)phenyl)piperazine; 4-(3-Bromo-5-(trifluoromethyl)phenyl)-1-(tert-butoxycarbonyl)piperazine; tert-Butyl 4-[3-bromo-5-(trifluoromethyl)phenyl]piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(3-bromo-5-(trifluoromethyl)phenyl)piperazine; 444727-13-3; BOC-4-(3-Bromo-5-(trifluoromethyl)phenyl)piperazine; N-Boc-4-(3-Bromo-5-(trifluoromethyl)phenyl)piperazine
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4-(3-Bromo-5-(Trifluoromethyl)Phenyl)Piperazine-1-Carboxylate adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Every lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We operate under a quality management system and can provide material suitable for research and development under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0% Any single impurity ≤1.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.