Description

1-n-Cbz-2-Methylpiperazine is a versatile and highly functionalized piperazine derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a protected secondary amine and a chiral center, enabling the efficient construction of complex molecular architectures with high stereochemical control. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel pesticides and herbicides requiring specific stereochemistry for enhanced activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal complex formation.
• Peptidomimetics Construction: Integral for creating peptide analogs and mimetics in medicinal chemistry programs.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	1-n-Cbz-2-Methylpiperazine
CAS No.	444666-46-0
Molecular Formula	C14H20N2O2
Molecular Weight	248.32 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-2-methylpiperazine; 1-Carbobenzoxy-2-methylpiperazine; N-Cbz-2-Methylpiperazine; (2-Methylpiperazin-1-yl)(phenyl)methanone, N-Carbobenzyloxy protected; 2-Methyl-1-(phenylmethoxycarbonyl)piperazine; 1-(Benzyloxycarbonyl)-2-methylpiperazine; Piperazine, 1-[(phenylmethoxy)carbonyl]-2-methyl-; Z-2-Methylpiperazine
EINECS	Contact for details

Quality Control

Our 1-n-Cbz-2-Methylpiperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.