Description

4-(2-Aminobenzenesulfonyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, particularly in the construction of novel pharmacologically active molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers requiring reliable, high-quality intermediates for API synthesis. The product is supplied with full analytical documentation to ensure batch-to-batch consistency and support regulatory filings.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Protease Inhibitor Scaffold: Used in the development of inhibitors for various enzymes, leveraging the sulfonamide and protected piperazine functionalities.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating tool compounds to study biological pathways and protein function.
• Library Synthesis for High-Throughput Screening: Employed in combinatorial chemistry to generate diverse compound libraries for biological activity screening.
• Custom Synthesis Projects: A starting material for contract research and manufacturing organizations (CROs/CMOs) working on bespoke molecular entities for clients.

Basic Information

Product Name	4-(2-Aminobenzenesulfonyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	444087-23-4
Molecular Formula	C15H23N3O4S
Molecular Weight	341.42 g/mol
Synonyms	1-Boc-4-(2-aminobenzenesulfonyl)piperazine; tert-Butyl 4-(2-aminobenzenesulfonyl)piperazine-1-carboxylate; 4-(2-Aminophenylsulfonyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; N-Boc-4-(2-aminobenzenesulfonyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(2-aminobenzenesulfonyl)piperazine; Piperazine-1-carboxylic acid tert-butyl ester, 4-(2-aminobenzenesulfonyl) derivative; CAS 444087-23-4
EINECS	Contact for details

Quality Control

Our 4-(2-Aminobenzenesulfonyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full traceability and compliance with cGMP standards where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.