Description

1(2H)-Azulenone, 3,6,7,8-Tetrahydro-8-Hydroxy-3,8-Dimethyl-5-(1-Methylethyl)-, (3R,8S)- is a high-purity, stereochemically defined azulenone derivative. This compound is valued for its unique molecular framework, which serves as a critical chiral building block and intermediate in advanced organic synthesis. It is primarily sought by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in therapeutic areas requiring complex molecular architectures.
• Fine Chemical Synthesis: Used in the multi-step synthesis of specialty chemicals, flavors, fragrances, and advanced materials where its specific stereochemistry is essential.
• Academic & Contract Research: Serves as a valuable reference standard and starting material in university and CRO laboratories for methodological development and chemical biology studies.
• Natural Product Analog Production: Facilitates the synthesis of analogs of complex natural products that contain the azulenone or related sesquiterpenoid core structures.

Basic Information

Product Name	1(2H)-Azulenone, 3,6,7,8-Tetrahydro-8-Hydroxy-3,8-Dimethyl-5-(1-Methylethyl)-, (3R,8S)-
CAS No.	443128-65-2
Molecular Formula	C15H22O2
Molecular Weight	234.33 g/mol
Synonyms	(3R,8S)-8-Hydroxy-3,8-dimethyl-5-(propan-2-yl)-3,4,6,7-tetrahydroazulen-1(2H)-one; (3R,8S)-3,6,7,8-Tetrahydro-8-hydroxy-3,8-dimethyl-5-(1-methylethyl)-1(2H)-azulenone; (-)-Nootkatone epoxide derivative; Chiral azulenone intermediate; 1(2H)-Azulenone, 3,4,6,7-tetrahydro-8-hydroxy-3,8-dimethyl-5-(1-methylethyl)-, (3R,8S)-
EINECS	Contact for details

Quality Control

Our 1(2H)-Azulenone derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and stereochemical purity suitable for demanding synthetic applications. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% (3R,8S)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.