Description

1-((4-Chloro-3-Methoxyphenyl)Sulfonyl)-4-(4-Fluorophenyl)Piperazine is a high-purity, synthetically derived sulfonyl piperazine derivative, serving as a critical advanced pharmaceutical intermediate. Its molecular architecture, featuring distinct chloro, methoxy, and fluoro substituents, makes it a valuable building block for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of targeted therapeutic agents, particularly within central nervous system (CNS) and receptor-modulation research programs.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and development of new chemical entities (NCEs) and potential active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• CNS Drug Development: Employed in the synthesis of compounds targeting neurological receptors and pathways, given the piperazine moiety's prevalence in neuropharmacology.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex organic molecules for clinical trials.
• Biochemical Research: May serve as a tool compound or inhibitor in biochemical assays to study specific enzyme or receptor interactions.
• Academic Research: Utilized in university and institutional laboratories for advanced organic synthesis projects and pharmacological studies.

Basic Information

Product Name	1-((4-Chloro-3-Methoxyphenyl)Sulfonyl)-4-(4-Fluorophenyl)Piperazine
CAS No.	442552-72-9
Molecular Formula	C17H18ClFN2O3S
Molecular Weight	384.85 g/mol
Synonyms	4-(4-Fluorophenyl)-1-[(4-chloro-3-methoxyphenyl)sulfonyl]piperazine; 1-(4-Chloro-3-methoxyphenylsulfonyl)-4-(4-fluorophenyl)piperazine; 442552-72-9; 4-(4-Fluorophenyl)-1-(4-chloro-3-methoxybenzenesulfonyl)piperazine; 1-(4-Chloro-3-methoxy-benzenesulfonyl)-4-(4-fluoro-phenyl)-piperazine; 4-(4-Fluorophenyl)-1-((4-chloro-3-methoxyphenyl)sulfonyl)piperazine; 1-((4-Chloro-3-methoxyphenyl)sulfonyl)-4-(4-fluorophenyl)piperazine; 4-(4-Fluorophenyl)-1-(4-chloro-3-methoxyphenylsulfonyl)piperazine
EINECS	Contact for details

Quality Control

Our 1-((4-Chloro-3-Methoxyphenyl)Sulfonyl)-4-(4-Fluorophenyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere if long-term storage is required to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.