Description

3-Bromo-5-Chloropyrazine-2-Carbonitrile is a high-purity halogenated pyrazine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in its versatile reactivity, offering distinct sites for nucleophilic substitution and cross-coupling reactions to construct complex heterocyclic scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially kinase inhibitors and other biologically active heterocycles.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with pyrazine-based structures.
• Material Science Research: Serves as a precursor for creating functional organic materials, such as ligands for metal-organic frameworks (MOFs) or electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to introduce the pyrazine core into more complex molecules.
• Nucleophilic Aromatic Substitution: The halogen atoms provide reactive sites for displacement with various nucleophiles like amines and alkoxides.
• Chemical Library Development: Used in high-throughput and combinatorial chemistry for generating diverse compound libraries for screening.

Basic Information

Product Name	3-Bromo-5-Chloropyrazine-2-Carbonitrile
CAS No.	440124-25-4
Molecular Formula	C5H1BrClN3
Molecular Weight	218.44 g/mol
Synonyms	3-Bromo-5-chloropyrazine-2-carbonitrile; 2-Pyrazinecarbonitrile, 3-bromo-5-chloro-; 5-Chloro-3-bromopyrazine-2-carbonitrile; 3-Bromo-5-chloro-2-cyanopyrazine; 440124-25-4; 3-Bromo-5-chloro-pyrazine-2-carbonitrile; 2-Cyano-3-bromo-5-chloropyrazine
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Chloropyrazine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in a dark place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.