Description

(S)-(+)-1-[(4-Chlorophenyl)Phenylmethyl]Piperazine CAS NO 439858-21-6 is a high-purity, single-enantiomer chiral piperazine derivative, a critical building block in modern asymmetric synthesis. Its value lies in its role as a sophisticated intermediate for constructing complex molecules with defined stereochemistry, essential for achieving desired biological activity. This compound is primarily needed by pharmaceutical R&D and process chemistry teams developing new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high stereochemical purity.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and receptor modulators.
• Asymmetric Catalyst Ligand Precursor: Serves as a starting material for synthesizing specialized ligands used in enantioselective catalysis.
• Agrochemical Research: Used in the discovery of advanced, stereochemically pure pesticides and herbicides.
• Academic & Institutional Research: A valuable tool for chemists studying stereochemistry, reaction mechanisms, and novel synthetic pathways in university and corporate labs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions.

Basic Information

Product Name	(S)-(+)-1-[(4-Chlorophenyl)Phenylmethyl]Piperazine
CAS No.	439858-21-6
Molecular Formula	C17H19ClN2
Molecular Weight	286.80 g/mol
Synonyms	(S)-1-[(4-Chlorophenyl)(phenyl)methyl]piperazine; (S)-(+)-1-(4-Chlorobenzhydryl)piperazine; (S)-1-[(4-Chlorophenyl)diphenylmethyl]piperazine; (S)-1-(4-Chloro-α-phenylbenzyl)piperazine; (S)-Norclozapine Impurity; (S)-Enantiomer of Clozapine Intermediate; L-1-[(4-Chlorophenyl)Phenylmethyl]Piperazine
EINECS	Contact for details

Quality Control

Our (S)-(+)-1-[(4-Chlorophenyl)Phenylmethyl]Piperazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.