Description

(R)-4-n-Boc-Piperazine-2-Carboxylic Acid Methyl Ester CAS NO 438631-77-7 is a high-purity chiral piperazine derivative, serving as a critical pharmaceutical intermediate and building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules with high biological activity. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• API Synthesis: Used in the construction of complex molecules for Active Pharmaceutical Ingredients (APIs), leveraging its protected amine and ester functionalities.
• Peptidomimetics & Bioactive Molecule Development: Integral for creating peptide analogs and other bioactive compounds where the (R)-configured piperazine core is required.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective chemical reactions to introduce specific three-dimensional architecture.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized fine chemicals and custom intermediates.

Basic Information

Product Name	(R)-4-n-Boc-Piperazine-2-Carboxylic Acid Methyl Ester
CAS No.	438631-77-7
Molecular Formula	C12H22N2O4
Molecular Weight	258.32 g/mol
Synonyms	Methyl (R)-4-(tert-butoxycarbonyl)piperazine-2-carboxylate; (R)-1-Boc-piperazine-2-carboxylic acid methyl ester; (R)-Methyl 4-(tert-butoxycarbonyl)piperazine-2-carboxylate; (R)-1-tert-Butyl 2-methyl 1,4-piperazinedicarboxylate; (R)-4-Boc-piperazine-2-carboxylic acid methyl ester; (R)-N-Boc-piperazine-2-carboxylic acid methyl ester; (2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic acid methyl ester; (R)-1-N-Boc-2-piperazinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our (R)-4-n-Boc-Piperazine-2-Carboxylic Acid Methyl Ester is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request, supporting regulatory compliance for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.