Description

n-4-Boc-2-Piperazinecarboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative that serves as a critical building block in modern organic synthesis. This compound is essential for the efficient construction of complex molecular architectures, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of drug candidates, particularly those containing piperazine or morpholine scaffolds, such as kinase inhibitors, GPCR modulators, and antiviral agents.
• Peptidomimetic Synthesis: Used in the construction of peptide analogs and peptidomimetics where the protected carboxylic acid and secondary amine functionalities allow for selective coupling and deprotection strategies.
• Combinatorial Chemistry: Serves as a versatile scaffold in solid-phase and solution-phase parallel synthesis libraries for high-throughput screening and lead optimization.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides that incorporate heterocyclic amine motifs.
• Ligand and Catalyst Development: Useful precursor for creating chiral auxiliaries, organocatalysts, and metal-complexing ligands used in asymmetric synthesis.
• Polymer and Material Science: Can be incorporated into specialty polymers, dendrimers, and functional materials to introduce specific chemical reactivity or biological activity.

Basic Information

Product Name	n-4-Boc-2-Piperazinecarboxylic Acid tert-Butyl Ester
CAS No.	438631-75-5
Molecular Formula	C14H26N2O4
Molecular Weight	286.37 g/mol
Synonyms	1-Boc-2-(tert-Butoxycarbonyl)piperazine; 1-(tert-Butoxycarbonyl)-2-(tert-butoxycarbonyl)piperazine; 1,2-Bis(tert-butoxycarbonyl)piperazine; 1-Boc-2-Boc-piperazine; tert-Butyl 4-[(tert-butoxy)carbonyl]-2-piperazinecarboxylate; Piperazine-1,2-dicarboxylic acid bis(tert-butyl ester); 1,2-Di-Boc-piperazine; 1,2-Piperazinedicarboxylic acid, 1,2-bis(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our n-4-Boc-2-Piperazinecarboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if frequent access is required. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.