Description

trans-Methyl 1-Benzyl-4-(4-Methoxyphenyl)Pyrrolidine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry. This compound is critical for the synthesis of complex molecules, offering a defined chiral center essential for developing active pharmaceutical ingredients (APIs) with targeted biological activity. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and metabolic disorder research pipelines.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, especially for neurological and psychiatric applications.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex pyrrolidine-based heterocycles and studying structure-activity relationships (SAR).
• Precursor for API Development: Serves as a critical precursor in multi-step synthetic routes for potential active pharmaceutical ingredients (APIs).
• Asymmetric Catalysis Studies: Employed as a substrate or ligand precursor in the development and testing of new asymmetric catalytic methodologies.
• Chemical Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	trans-Methyl 1-Benzyl-4-(4-Methoxyphenyl)Pyrrolidine-3-Carboxylate
CAS No.	438492-38-7
Molecular Formula	C20H23NO3
Molecular Weight	325.40 g/mol
Synonyms	Methyl (3R,4S)-1-benzyl-4-(4-methoxyphenyl)pyrrolidine-3-carboxylate; (3R,4S)-1-Benzyl-4-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid methyl ester; 1-Benzyl-4-(4-methoxyphenyl)-3-pyrrolidinecarboxylic acid methyl ester, trans-; trans-1-Benzyl-4-(p-methoxyphenyl)-3-pyrrolidinecarboxylic acid methyl ester; 438492-38-7; Methyl 1-benzyl-4-(4-methoxyphenyl)-3-pyrrolidinecarboxylate
EINECS	Contact for details

Quality Control

Our trans-Methyl 1-Benzyl-4-(4-Methoxyphenyl)Pyrrolidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.