Description

tert-Butyl (3R)-4-(Chlorocarbonyl)-3-Methylpiperazine-1-Carboxylate is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. Its value lies in its dual functionality as a protected amine and an activated carbonyl chloride, enabling efficient and stereoselective construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly for developing active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• API Development: Used in research and process development for constructing the core piperazine scaffolds found in numerous bioactive compounds.
• Peptidomimetics & Protease Inhibitors: Facilitates the introduction of the (3R)-3-methylpiperazine moiety into peptide-like structures for drug discovery programs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block to induce stereoselectivity in multi-step synthetic routes.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom chemical synthesis services targeting novel chemical entities.
• Agrochemical Research: Potential intermediate in the development of advanced, chiral agrochemicals requiring specific stereochemistry for efficacy.

Basic Information

Product Name	tert-Butyl (3R)-4-(Chlorocarbonyl)-3-Methylpiperazine-1-Carboxylate
CAS No.	438050-54-5
Molecular Formula	C11H19ClN2O3
Molecular Weight	262.73 g/mol
Synonyms	1-Boc-3(R)-Methylpiperazine-4-carbonyl Chloride; tert-Butyl (3R)-4-(Chloroformyl)-3-methylpiperazine-1-carboxylate; (3R)-1-(tert-Butoxycarbonyl)-3-methylpiperazine-4-carbonyl chloride; 1-N-Boc-3(R)-Methylpiperazine-4-carboxylic Acid Chloride; Boc-3(R)-Methylpiperazine-4-COCl; (R)-1-Boc-3-Methylpiperazine-4-carbonyl Chloride; tert-Butyl 4-(chlorocarbonyl)-3-methylpiperazine-1-carboxylate, (3R)-
EINECS	Contact for details

Quality Control

Our tert-Butyl (3R)-4-(Chlorocarbonyl)-3-Methylpiperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistency. Certificates of Analysis (COA) are provided, detailing parameters such as assay (HPLC), chiral purity, and identity (IR, NMR). We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.