Description

(3R,5S)-Rel-4-(Chlorocarbonyl)-3,5-Dimethyl-1-Piperazinecarboxylic Acid tert-Butyl Ester is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. Its core value lies in providing a protected, reactive scaffold for constructing complex pharmaceutical molecules, particularly active pharmaceutical ingredients (APIs) and intermediates. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality chiral intermediates.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• API Synthesis: Used in the construction of complex, stereochemically defined active pharmaceutical ingredients (APIs) requiring the (3R,5S) piperazine core.
• Peptidomimetics Research: Serves as a constrained scaffold in the design and synthesis of peptidomimetic compounds for drug discovery programs.
• Asymmetric Catalysis Ligand Precursor: Potential precursor for the development of chiral ligands and catalysts used in asymmetric synthesis.
• Agrochemical Intermediate: Intermediate in the synthesis of advanced, chiral agrochemicals with specific biological activity.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects requiring high stereochemical fidelity.

Basic Information

Product Name	(3R,5S)-Rel-4-(Chlorocarbonyl)-3,5-Dimethyl-1-Piperazinecarboxylic Acid tert-Butyl Ester
CAS No.	438050-53-4
Molecular Formula	C12H21ClN2O3
Molecular Weight	276.76 g/mol
Synonyms	1-Boc-3,5-dimethylpiperazine-4-carbonyl chloride; tert-Butyl (3R,5S)-4-(chlorocarbonyl)-3,5-dimethylpiperazine-1-carboxylate; (3R,5S)-1-(tert-Butoxycarbonyl)-3,5-dimethylpiperazine-4-carbonyl chloride; 1-N-Boc-3,5-dimethylpiperazine-4-carboxylic acid chloride; (3R,5S)-4-(Chlorocarbonyl)-3,5-dimethylpiperazine-1-carboxylic acid tert-butyl ester; Boc-3,5-dimethylpiperazine-4-COCl; Rel-(3R,5S)-1-Boc-3,5-dimethylpiperazine-4-carbonyl chloride
EINECS	Contact for details

Quality Control

Our (3R,5S)-Rel-4-(Chlorocarbonyl)-3,5-Dimethyl-1-Piperazinecarboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot undergoes rigorous analytical testing, including chiral purity verification by HPLC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.