Description

(3R,5R)-1-Boc-3,5-Dimethylpiperazine CAS NO 438049-91-3 is a high-purity, chiral piperazine derivative featuring a tert-butoxycarbonyl (Boc) protecting group on one nitrogen atom. This compound serves as a critical chiral building block and intermediate in the synthesis of complex pharmaceutical molecules, particularly those requiring specific stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) drugs and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• API Development: Integral in constructing the core piperazine scaffold found in numerous bioactive molecules and approved pharmaceuticals.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the exploration of new chemical entities (NCEs).
• Peptidomimetics: Used in the design and synthesis of peptide analogs and conformationally restricted scaffolds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.

Basic Information

Product Name	(3R,5R)-1-Boc-3,5-Dimethylpiperazine
CAS No.	438049-91-3
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	1-Boc-(3R,5R)-3,5-Dimethylpiperazine; tert-Butyl (3R,5R)-3,5-dimethylpiperazine-1-carboxylate; (3R,5R)-1-(tert-Butoxycarbonyl)-3,5-dimethylpiperazine; (3R,5R)-3,5-Dimethylpiperazine-1-carboxylic acid tert-butyl ester; (R,R)-1-Boc-3,5-dimethylpiperazine; BOC-(3R,5R)-3,5-Dimethylpiperazine; 1-N-Boc-(3R,5R)-3,5-dimethylpiperazine
EINECS	Contact for details

Quality Control

Our (3R,5R)-1-Boc-3,5-Dimethylpiperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by spectroscopic methods. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with every shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with current Good Manufacturing Practice (cGMP) standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.