Description

3-Piperazin-1-Ylthiolane 1,1-Dioxide Dihydrochloride is a high-purity, functionalized piperazine derivative primarily used as a critical building block in pharmaceutical research and development. This compound matters for its role in constructing complex molecular architectures, particularly in the synthesis of potential drug candidates targeting central nervous system disorders. Pharmaceutical companies, contract research organizations (CROs), and advanced academic laboratories need this specialized intermediate for medicinal chemistry programs, process development, and scale-up activities.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel therapeutic agents, particularly for neurological and psychiatric applications.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the piperazine-thiolane dioxide pharmacophore.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scale-up and route development for Active Pharmaceutical Ingredient (API) synthesis.
• Bioconjugation & Probe Development: Utilized in the creation of chemical probes and bioconjugates for biochemical and pharmacological research due to its functional handles.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery campaigns.

Basic Information

Product Name	3-Piperazin-1-Ylthiolane 1,1-Dioxide Dihydrochloride
CAS No.	436852-26-5
Molecular Formula	C8H18Cl2N2O2S
Molecular Weight	277.21 g/mol
Synonyms	3-(Piperazin-1-yl)thiolane 1,1-dioxide dihydrochloride; 1,1-Dioxo-1lambda6-thiolan-3-yl-piperazine dihydrochloride; 3-Piperazin-1-yl-thiolane-1,1-dioxide dihydrochloride; Thiolane-1,1-dioxide, 3-(1-piperazinyl)-, dihydrochloride; 3-(Piperazin-1-yl)tetrahydrothiophene 1,1-dioxide dihydrochloride
EINECS	Contact for details

Quality Control

Our 3-Piperazin-1-Ylthiolane 1,1-Dioxide Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.