Description

(E)-n-[4-[n-(3-Methoxypyrazin-2-Yl)Sulfamoyl]Phenyl]-3-(5-Nitrothiophene-2-Yl)Acrylamide is a high-purity, synthetic organic compound designed for advanced research and development applications. This molecule is of significant interest due to its complex heterocyclic structure, which incorporates pyrazine, sulfonamide, and nitro-thiophene moieties, making it a valuable pharmacological research intermediate. It is primarily utilized by pharmaceutical R&D laboratories and biotechnology companies engaged in the discovery and synthesis of novel bioactive compounds.

Application

• Pharmaceutical Research Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly for targeted therapies.
• Kinase Inhibitor Development: Used in the research and development of potential kinase inhibitors due to its specific molecular scaffold.
• Biochemical Assay Standard: Acts as a reference standard or analytical control in high-throughput screening (HTS) and assay validation.
• Medicinal Chemistry Studies: Employed in structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and chemical biology.
• Contract Research Organization (CRO) Projects: Supplied to CROs for client-sponsored drug discovery programs requiring specialized intermediates.

Basic Information

Product Name	(E)-n-[4-[n-(3-Methoxypyrazin-2-Yl)Sulfamoyl]Phenyl]-3-(5-Nitrothiophene-2-Yl)Acrylamide
CAS No.	432531-71-0
Molecular Formula	C20H16N6O6S2
Molecular Weight	500.51 g/mol
Synonyms	(E)-N-[4-[[(3-Methoxypyrazin-2-yl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)acrylamide; 3-(5-Nitro-2-thienyl)-N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-2-propenamide; TAK-715 (Research Code); N-[4-[(3-Methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide; p38 MAP Kinase Inhibitor (Analog); 432531-71-0; Acrylamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-, (E)-
EINECS	Contact for details

Quality Control

Our (E)-n-[4-[n-(3-Methoxypyrazin-2-Yl)Sulfamoyl]Phenyl]-3-(5-Nitrothiophene-2-Yl)Acrylamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.