Description

(2R,5S)-tert-Butyl 4-Benzyl-2,5-Dimethylpiperazine-1-Carboxylate CAS NO 431062-00-9 is a high-purity, stereochemically defined piperazine derivative used as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of active pharmaceutical ingredients (APIs), particularly in creating novel therapeutics targeting the central nervous system and other disease areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Ligand Precursor: Used in the preparation of chiral ligands for asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Peptidomimetic Research: Serves as a constrained dipeptide isostere or scaffold in medicinal chemistry for designing protease inhibitors and receptor modulators.
• Chemical Biology Probe Development: Incorporated into molecular probes to study enzyme function and protein-protein interactions due to its defined stereochemistry and functional handles.
• Custom Synthesis Building Block: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic projects requiring high stereochemical fidelity.
• Academic Research: Utilized in university laboratories for methodological development in organic synthesis and studies of stereochemistry.

Basic Information

Product Name	(2R,5S)-tert-Butyl 4-Benzyl-2,5-Dimethylpiperazine-1-Carboxylate
CAS No.	431062-00-9
Molecular Formula	C18H28N2O2
Molecular Weight	304.43 g/mol
Synonyms	1-Boc-4-benzyl-2,5-dimethyl-(2R,5S)-piperazine; tert-Butyl (2R,5S)-4-benzyl-2,5-dimethylpiperazine-1-carboxylate; (2R,5S)-1-(tert-Butoxycarbonyl)-4-benzyl-2,5-dimethylpiperazine; (2R,5S)-N-Boc-4-benzyl-2,5-dimethylpiperazine; BOC-(2R,5S)-4-Benzyl-2,5-dimethylpiperazine; 1-N-BOC-4-Benzyl-2,5-dimethyl-(2R,5S)-piperazine; (2R,5S)-1-Boc-4-benzyl-2,5-dimethylpiperazine
EINECS	Contact for details

Quality Control

Our (2R,5S)-tert-Butyl 4-Benzyl-2,5-Dimethylpiperazine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.