Description

2-Chloro-6-(Prop-2-Yn-1-Yloxy)Pyrazine is a specialized pyrazine derivative featuring both a chloro and a propargyl ether functional group, making it a versatile and valuable building block in advanced organic synthesis. This compound is particularly significant for its role in the development of complex molecules, especially in pharmaceutical research and agrochemical discovery. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel heterocyclic frameworks and active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Development: Used in the creation of new herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Chemical Biology Probe Synthesis: The alkyne handle facilitates "click chemistry" (CuAAC) for bioconjugation and labeling applications in proteomics and diagnostics.
• Academic & Industrial R&D: Employed in method development and exploratory chemistry for constructing complex, functionalized pyrazine libraries.

Basic Information

Product Name	2-Chloro-6-(Prop-2-Yn-1-Yloxy)Pyrazine
CAS No.	426832-47-5
Molecular Formula	C7H5ClN2O
Molecular Weight	168.58 g/mol
Synonyms	2-Chloro-6-(2-propynyloxy)pyrazine; 6-Chloro-3-(2-propynyloxy)pyrazine; 2-Chloro-6-(prop-2-yn-1-yloxy)pyrazine; 2-Chloro-6-propargyloxypyrazine; Pyrazine, 2-chloro-6-(2-propynyloxy)-; 426832-47-5; 2-Chloro-6-(prop-2-ynyloxy)pyrazine
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-(Prop-2-Yn-1-Yloxy)Pyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.