Description

tert-Butyl 4-((3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily needed by pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and fine chemical suppliers engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Development: Used in the process development and scale-up of new active pharmaceutical ingredients, leveraging its boc-protected piperidine moiety.
• CNS Drug Synthesis: Particularly relevant for constructing molecules intended to cross the blood-brain barrier for treating conditions like depression, anxiety, or schizophrenia.
• Oncology Research Compounds: Employed in the synthesis of potential kinase inhibitors or other targeted cancer therapies due to its benzoxazinone core.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 4-((3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperidine-1-carboxylate
CAS No.	420786-32-9
Molecular Formula	C20H26N2O4
Molecular Weight	358.44 g/mol
Synonyms	1-Boc-4-((3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperidine; 1-(tert-Butoxycarbonyl)-4-[(3-oxo-4H-1,4-benzoxazin-6-yl)methyl]piperidine; 4-[(3-Oxo-2,4-dihydro-1,4-benzoxazin-6-yl)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-[(3-oxo-2H-1,4-benzoxazin-6-yl)methyl]piperidine-1-carboxylate; 420786-32-9; 6-[(1-Boc-4-piperidyl)methyl]-2H-1,4-benzoxazin-3(4H)-one; BOC-4-((3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazin-6-Yl)Methyl)Piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-((3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperidine-1-carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.