Description

(2R)-2-(4-Fluoro-2-Methylphenyl)-4-Piperidinone CAS NO 414910-12-6 is a high-purity chiral piperidinone derivative, a critical advanced pharmaceutical intermediate (API) and building block in modern organic synthesis. Its value lies in its defined stereochemistry and functionalized structure, enabling the efficient construction of complex molecules with high enantiomeric purity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel active compounds targeting the central nervous system and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of potential drug candidates, especially in neurological and psychiatric research.
• Agrochemical Synthesis: Used in the research and development of novel, enantiomerically pure pesticides and herbicides.
• Asymmetric Catalysis Research: Serves as a valuable ligand precursor or substrate in the development of new catalytic systems.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile piperidinone core.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development and quality control in API manufacturing.
• Academic & Contract Research: A crucial reagent for synthetic methodology development and exploratory chemistry in academic and CRO laboratories.

Basic Information

Product Name	(2R)-2-(4-Fluoro-2-Methylphenyl)-4-Piperidinone
CAS No.	414910-12-6
Molecular Formula	C12H14FNO
Molecular Weight	207.25 g/mol
Synonyms	(R)-2-(4-Fluoro-2-methylphenyl)piperidin-4-one; 4-Piperidinone, 2-(4-fluoro-2-methylphenyl)-, (2R)-; (2R)-2-(4-Fluoro-2-methylphenyl)-4-piperidinone; (R)-2-(4-Fluoro-o-tolyl)piperidin-4-one; 414910-12-6; (R)-2-(4-Fluoro-2-methylphenyl)-4-piperidone; (2R)-2-(4-Fluoro-2-methylphenyl)piperidin-4-one
EINECS	Contact for details

Quality Control

Our (2R)-2-(4-Fluoro-2-Methylphenyl)-4-Piperidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98%), enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.