Description

Piperazine, 1-[[(2R)-Tetrahydro-2-Furanyl]Carbonyl]- (9Ci) is a specialized chiral piperazine derivative, a high-value building block in modern synthetic chemistry. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. Pharmaceutical R&D and fine chemical synthesis teams need this precisely defined chiral scaffold to create novel therapeutic agents with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in neuroscience and psychiatry.
• API Development: Used in research and process development for Active Pharmaceutical Ingredients requiring a specific (R)-configured tetrahydrofuroyl-piperazine moiety.
• Asymmetric Synthesis: Serves as a versatile precursor in asymmetric catalysis and chiral pool synthesis for complex molecule construction.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs.
• Fine Chemical Production: Used in the multi-step synthesis of advanced agrochemicals and specialty materials.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in regulatory environments.

Basic Information

Product Name	Piperazine, 1-[[(2R)-Tetrahydro-2-Furanyl]Carbonyl]- (9Ci)
CAS No.	412334-56-6
Molecular Formula	C9H16N2O2
Molecular Weight	184.24 g/mol
Synonyms	1-[(2R)-Tetrahydrofuran-2-carbonyl]piperazine; (R)-1-(Tetrahydrofuran-2-carbonyl)piperazine; (R)-Tetrahydrofuran-2-carboxylic acid piperazin-1-ylamide; (R)-N-(Piperazin-1-yl)tetrahydrofuran-2-carboxamide; (2R)-1-(1-Piperazinylcarbonyl)tetrahydrofuran; (R)-Tetrahydro-2-furoyl piperazine; 412334-56-6; UNII-6Q2I7803JN
EINECS	Contact for details

Quality Control

Our Piperazine, 1-[[(2R)-Tetrahydro-2-Furanyl]Carbonyl]- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and can be tailored to meet specific customer or regulatory requirements (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.