Description

3-(R)-Amino-Piperidin-2-One Hydrochloride is a high-purity chiral piperidinone derivative, serving as a critical building block in modern pharmaceutical synthesis. Its value lies in providing a stereochemically defined scaffold essential for developing potent and selective active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and metabolic disorder research.
• API Development: Used as a core structural component in the research and scale-up of new Active Pharmaceutical Ingredients (APIs).
• Protease Inhibitor Synthesis: Employed in the construction of complex molecules targeting various protease enzymes.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective chemical transformations.
• Medicinal Chemistry Research: Serves as a versatile scaffold for generating compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Acts as a starting material for developing tool compounds and molecular probes to study biological pathways.

Basic Information

Product Name	3-(R)-Amino-Piperidin-2-One Hydrochloride
CAS No.	406216-02-2
Molecular Formula	C5H11N2O·HCl
Molecular Weight	150.62 g/mol (Free base: 114.16 g/mol)
Synonyms	(R)-3-Aminopiperidin-2-one hydrochloride; (3R)-3-Amino-2-piperidinone hydrochloride; 3R-Amino-2-piperidinone HCl; 2-Piperidinone, 3-amino-, hydrochloride, (3R)-; (R)-3-Amino-delta2-piperidinone hydrochloride; (R)-3-Azanylpiperidin-2-one hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(R)-Amino-Piperidin-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.