Description

(R)-4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester is a high-purity chiral piperazine derivative, serving as a critical building block in advanced pharmaceutical synthesis. This compound is essential for medicinal chemists developing targeted therapeutics due to its role as a key intermediate for constructing complex molecular architectures. It is primarily utilized in the research and development of active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) agents and other specialized drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of targeted molecular libraries for high-throughput screening.
• Peptidomimetic Development: Serves as a constrained scaffold for designing and synthesizing peptide analogs with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective reactions to introduce the (R)-configuration into complex molecules.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and research institutions for custom synthesis projects and process development.

Basic Information

Product Name	(R)-4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester
CAS No.	405175-79-3
Molecular Formula	C15H20N2O4
Molecular Weight	292.33 g/mol
Synonyms	(R)-1-Cbz-4-Piperazinecarboxylic Acid Methyl Ester; Methyl (R)-1-[(benzyloxy)carbonyl]-4-piperazinecarboxylate; (R)-1-Benzyloxycarbonylpiperazine-4-carboxylic Acid Methyl Ester; (R)-Methyl 1-Cbz-4-piperazinecarboxylate; (R)-Methyl 1-[(benzyloxy)carbonyl]piperazine-4-carboxylate; (R)-4-(Benzyloxycarbonyl)piperazine-2-carboxylic Acid Methyl Ester; (R)-N-Cbz-Piperazine-4-carboxylic Acid Methyl Ester; (2R)-1-[(Benzyloxy)carbonyl]piperazine-2-carboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our (R)-4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.