Description

1-n-Boc-4-(2-Fluorophenyl)-4-Hydroxypiperidine is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of complex molecules, particularly in the creation of novel central nervous system (CNS) active agents and receptor-targeted therapeutics. It is primarily required by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potent, selective receptor ligands and modulators.
• CNS Drug Development: Building block for research into antipsychotic, antidepressant, and anxiolytic drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic targets.
• API Synthesis: Integral component in multi-step synthetic routes for complex active pharmaceutical ingredients.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable, GMP-compliant manufacturing processes.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for clients.

Basic Information

Product Name	1-n-Boc-4-(2-Fluorophenyl)-4-Hydroxypiperidine
CAS No.	403806-35-9
Molecular Formula	C16H22FNO3
Molecular Weight	295.35 g/mol
Synonyms	1-Boc-4-(2-Fluorophenyl)-4-hydroxypiperidine; tert-Butyl 4-(2-fluorophenyl)-4-hydroxypiperidine-1-carboxylate; 4-(2-Fluorophenyl)-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 4-(2-Fluorophenyl)-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; N-Boc-4-(2-fluorophenyl)-4-hydroxypiperidine; 1-(tert-Butoxycarbonyl)-4-(2-fluorophenyl)-4-hydroxypiperidine; 403806-35-9; 4-Hydroxy-4-(2-fluorophenyl)piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-n-Boc-4-(2-Fluorophenyl)-4-Hydroxypiperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is available for every batch upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.