Description

Nebentan CAS NO 403604-85-3 is a high-purity, non-peptide endothelin receptor antagonist of significant interest in pharmaceutical research and development. This compound is valued for its specific biological activity, making it a critical intermediate or reference standard for advanced therapeutic studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in cardiovascular and renal disease research, as well as in the synthesis of novel drug candidates.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of endothelin receptor antagonist therapies.
• Cardiovascular Disease Studies: Used in preclinical and clinical research targeting conditions such as pulmonary arterial hypertension and heart failure.
• Biochemical Assay Development: Employed as a selective ligand in receptor binding assays and pharmacological profiling to study endothelin system pathways.
• Academic Research: Utilized in university and institutional labs for fundamental studies on vascular biology and signal transduction mechanisms.
• Contract Manufacturing: Supplied as a building block for the cGMP-compliant synthesis of advanced drug substances for clinical trials.

Basic Information

Product Name	Nebentan
CAS No.	403604-85-3
Molecular Formula	C29H30N2O6S
Molecular Weight	534.63 g/mol
Synonyms	N-[6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-4-(1,3-benzodioxol-5-yl)-2-thiophenecarboxamide; BSF 208075; Nebentan; BSF-208075; BSF208075; UNII-7F3WYV42P0; 7F3WYV42P0
EINECS	Contact for details

Quality Control

Our Nebentan is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity determination by HPLC, and control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support development projects requiring material that meets research-grade, GMP-starting material, or reference standard criteria.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.