Description

(2S,4S)-4-[4-(3-Methyl-1-Phenyl-1H-Pyrazol-5-Yl)-1-Piperazinyl]-2-(3-Thiazolidinylcarbonyl)-1-Pyrrolidinecarboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex chiral structure. This compound is of significant value in the research and development of novel therapeutic agents, particularly as a key building block in medicinal chemistry. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules and potential drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of complex drug molecules, particularly those targeting neurological or metabolic pathways.
• Medicinal Chemistry Research: Used as a scaffold or precursor for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) in drug discovery programs.
• Process Chemistry Development: Employed in the optimization and scale-up of synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Biochemical Research: May be utilized as a tool compound or ligand in biochemical assays to study specific enzyme or receptor interactions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client-specific projects.

Basic Information

Product Name	(2S,4S)-4-[4-(3-Methyl-1-Phenyl-1H-Pyrazol-5-Yl)-1-Piperazinyl]-2-(3-Thiazolidinylcarbonyl)-1-Pyrrolidinecarboxylic Acid tert-Butyl Ester
CAS No.	401566-80-1
Molecular Formula	C27H38N6O3S
Molecular Weight	526.70 g/mol
Synonyms	tert-Butyl (2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate; (2S,4S)-1-(tert-Butoxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-(thiazolidine-3-carbonyl)pyrrolidine; 401566-80-1; UNII-9I4KQ2B8YI; Pyrrolidinecarboxylic acid, 4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4S)-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development and commercial projects with specifications that can meet the requirements of GMP and ICH Q7 guidelines for APIs and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.