Description

1-(3,4-Dichlorophenyl)-4-(5-Nitro-2-Pyridinyl)Piperazine is a high-purity, advanced pharmaceutical intermediate characterized by its distinct piperazine-based heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly within central nervous system (CNS) research and development. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions engaged in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel therapeutic agents, especially for neurological and psychiatric targets.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key structural component in the development of candidate APIs, particularly those with piperazine and aryl chloride pharmacophores.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation of related drug substances.
• Biochemical Research: Utilized in vitro studies to investigate interactions with biological targets such as receptors or enzymes.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up activities.

Basic Information

Item	Detail
Product Name	1-(3,4-Dichlorophenyl)-4-(5-Nitro-2-Pyridinyl)Piperazine
CAS No.	400088-96-2
Molecular Formula	C15H12Cl2N4O2
Molecular Weight	363.19 g/mol
Synonyms	1-(3,4-Dichlorophenyl)-4-(5-nitropyridin-2-yl)piperazine; 2-[4-(3,4-Dichlorophenyl)piperazin-1-yl]-5-nitropyridine; 5-Nitro-2-[4-(3,4-dichlorophenyl)-1-piperazinyl]pyridine; 400088-96-2; (5-Nitro-2-pyridinyl)-[4-(3,4-dichlorophenyl)piperazin-1-yl]methanone (tautomer); 1-(3,4-Dichlorophenyl)-4-(5-nitro-2-pyridyl)piperazine
EINECS	Contact for details

Quality Control

Our 1-(3,4-Dichlorophenyl)-4-(5-Nitro-2-Pyridinyl)Piperazine is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions. For long-term storage, consider using an inert atmosphere to prevent potential oxidation.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.