Description

Phosphonium,[(3'S)-1'-[(1,1-Dimethylethoxy)Carbonyl]-2-Oxo[1,3'-Bipyrrolidin]-3-Yl]Triphenyl-,Bromide is a high-purity, advanced pharmaceutical intermediate and chiral building block. This compound is valued for its role in facilitating complex organic syntheses, particularly in the construction of nitrogen-containing heterocycles. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly those containing pyrrolidine-based scaffolds.
• Asymmetric Synthesis: Employed as a specialized reagent or ligand precursor in catalytic asymmetric transformations to induce chirality in target molecules.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics and protease inhibitors due to its constrained, bicyclic proline-like structure.
• Medicinal Chemistry: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Academic & Industrial R&D: A valuable tool for synthetic organic chemists exploring new methodologies and reaction pathways in heterocyclic chemistry.

Basic Information

Product Name	Phosphonium,[(3'S)-1'-[(1,1-Dimethylethoxy)Carbonyl]-2-Oxo[1,3'-Bipyrrolidin]-3-Yl]Triphenyl-,Bromide
CAS No.	400045-51-4
Molecular Formula	C₃₃H₃₉BrN₂O₃P
Molecular Weight	631.56 g/mol
Synonyms	(3'S)-1'-(tert-Butoxycarbonyl)-2-oxo-1,3'-bipyrrolidin-3-yl)triphenylphosphonium bromide; (3'S)-N-Boc-2-oxo-1,3'-bipyrrolidin-3-yl)triphenylphosphonium bromide; Triphenyl((3'S)-1'-((tert-butoxycarbonyl)-2-oxo-[1,3'-bipyrrolidin]-3-yl)phosphonium bromide; N-Boc protected bicyclic pyrrolidinyl phosphonium salt; Chiral bicyclic proline-derived phosphonium salt; 400045-51-4; [1,3'-Bipyrrolidin]-3-yl, 1'-[(1,1-dimethylethoxy)carbonyl]-2-oxo-, (3'S)-, triphenylphosphonium bromide
EINECS	Contact for details

Quality Control

Our Phosphonium,[(3'S)-1'-[(1,1-Dimethylethoxy)Carbonyl]-2-Oxo[1,3'-Bipyrrolidin]-3-Yl]Triphenyl-,Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and advanced synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.