Description

Sulindac Sulfide CAS NO 49627-27-2 is the principal active metabolite of the non-steroidal anti-inflammatory drug (NSAID) Sulindac. This compound matters for its potent role as a key intermediate and reference standard in pharmaceutical research and development. It is primarily needed by pharmaceutical manufacturers, analytical laboratories, and research institutions focused on anti-inflammatory drug discovery, metabolic studies, and quality control.

Application

• Pharmaceutical Intermediate: Critical synthesis component for the production of the NSAID Sulindac and related analogs.
• Biochemical Research: Used as a reference standard in studies investigating the metabolic pathways, pharmacokinetics, and bioactivation of Sulindac.
• Analytical Standard: Serves as a high-purity standard for HPLC, LC-MS, and other chromatographic methods in quality control and assay development.
• Mechanistic Studies: Employed in pharmacological research to explore the anti-inflammatory and potential chemopreventive mechanisms of Sulindac derivatives.
• API Development: Utilized in the development and scale-up processes for active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	Sulindac Sulfide
CAS No.	49627-27-2
Molecular Formula	C20H17FO2S
Molecular Weight	340.41 g/mol
Synonyms	(Z)-5-Fluoro-2-methyl-1-[(4-methylsulfinyl)phenyl]methylene-1H-indene-3-acetic acid sulfide; (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid sulfide; Sulindac sulfide; FGN-1; Z-5-Fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-3-indenylacetic acid sulfide; 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1Z)-, sulfide; 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)-
EINECS	256-404-5

Quality Control

Our Sulindac Sulfide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets high-grade standards suitable for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.