Description

[6R-(6Alpha,7Beta)]-3-Methyl-8-Oxo-7-(Phenylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid 5-Oxide is a key advanced pharmaceutical intermediate, specifically a penicillanic acid sulfoxide derivative. This compound is of critical importance in the synthesis of semi-synthetic β-lactam antibiotics, where it serves as a versatile building block. It is primarily required by manufacturers in the pharmaceutical and fine chemical sectors for research, development, and production of active pharmaceutical ingredients (APIs).

Application

• Synthesis of β-Lactam Antibiotics: A crucial precursor in the multi-step synthesis of semi-synthetic penicillins and cephalosporins.
• Pharmaceutical Intermediate: Used in the production of specific antibiotic APIs, leveraging its reactive sulfoxide group for further chemical modifications.
• Research & Development: Serves as a standard or starting material in medicinal chemistry for developing new antimicrobial agents.
• Process Chemistry: Employed in scale-up and optimization studies for efficient antibiotic manufacturing processes.
• Fine Chemical Synthesis: Utilized as a specialized chiral building block for synthesizing complex organic molecules beyond antibiotics.

Basic Information

Product Name	[6R-(6Alpha,7Beta)]-3-Methyl-8-Oxo-7-(Phenylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid 5-Oxide
CAS No.	49586-46-1
Molecular Formula	C16H16N2O5S
Molecular Weight	348.37 g/mol
Synonyms	(6R,7R)-7-Phenylacetamido-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-oxide; Penicillanic Acid 1-Oxide Derivative; 6-APA Sulfoxide Derivative; 7-ADCA Sulfoxide Precursor; 3-Methyl-7-phenylacetamidopenicillanic acid S-oxide; (6R,7R)-3-Methyl-7-(2-phenylacetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-oxide
EINECS	Contact for details

Quality Control

Our [6R-(6Alpha,7Beta)]-3-Methyl-8-Oxo-7-(Phenylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid 5-Oxide is produced under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting compliance with cGMP and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.