Description

(S)-N,N'-Bis(p-Methoxybenzyl)-3-Isopropyl-Piperazine-2,5-Dione CAS NO 47981-55-5 is a high-purity, chiral piperazine-2,5-dione derivative, a key structural motif and advanced intermediate in modern organic synthesis. Its value lies in its role as a sophisticated building block for constructing complex molecules, particularly in the development of novel pharmaceuticals and bioactive compounds. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates for asymmetric synthesis and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of potential drug candidates, especially those targeting neurological disorders or as protease inhibitors.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to introduce stereochemical complexity.
• Medicinal Chemistry Research: Serves as a core scaffold for constructing compound libraries in structure-activity relationship (SAR) studies.
• Peptidomimetic Development: The piperazine-2,5-dione (diketopiperazine) core is a privileged structure in designing peptidomimetics with improved metabolic stability.
• Agrochemical Synthesis: Potential intermediate in the development of novel, chiral active ingredients for crop protection.
• Ligand and Catalyst Preparation: Can be utilized to develop novel chiral ligands for metal-catalyzed transformations.

Basic Information

Product Name	(S)-N,N'-Bis(p-Methoxybenzyl)-3-Isopropyl-Piperazine-2,5-Dione
CAS No.	47981-55-5
Molecular Formula	C24H30N2O4
Molecular Weight	410.51 g/mol
Synonyms	(S)-3-Isopropyl-1,4-bis(4-methoxybenzyl)piperazine-2,5-dione; (S)-1,4-Bis(4-methoxybenzyl)-3-(propan-2-yl)piperazine-2,5-dione; (S)-3-Isopropyl-1,4-bis(p-methoxybenzyl)-2,5-piperazinedione; (S)-N,N'-Di(4-methoxybenzyl)-3-isopropyl-2,5-diketopiperazine; (S)-3-Isopropyl-1,4-di(4-methoxybenzyl)piperazine-2,5-dione; (S)-3-(1-Methylethyl)-1,4-bis(4-methoxybenzyl)-2,5-piperazinedione
EINECS	Contact for details

Quality Control

Our (S)-N,N'-Bis(p-Methoxybenzyl)-3-Isopropyl-Piperazine-2,5-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral excess, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.