Description

3',5'-Dichlorofolic Acid is a key chemical intermediate and derivative of folic acid, distinguished by the strategic chlorination at the 3' and 5' positions of its phenyl ring. This structural modification is critical for altering biological activity and physicochemical properties, making it a valuable building block in advanced research and synthesis. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and synthesis of novel antifolate drugs and targeted therapeutic agents.
• Biochemical Research: Used as a reference standard and tool compound in enzymatic studies, particularly those involving dihydrofolate reductase (DHFR) and other folate-dependent pathways.
• Chemical Synthesis: Acts as a specialized building block for the preparation of more complex folic acid analogs and conjugates for various experimental applications.
• Academic & Institutional R&D: Employed in universities and research institutes for investigating structure-activity relationships (SAR) and metabolic pathways.

Basic Information

Product Name	3',5'-Dichlorofolic Acid
CAS No.	47748-46-9
Molecular Formula	C19H17Cl2N7O6
Molecular Weight	502.29 g/mol
Synonyms	N-[4-[[(2-Amino-3,5-dichloro-4-oxo-1,4-dihydro-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid; 3',5'-Dichloro-4-aminofolic acid; 3,5-Dichlorofolic acid; Pteroyl-3',5'-dichloro-L-glutamic acid; (2S)-2-[[4-[(2-Amino-3,5-dichloro-4-oxopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
EINECS	Contact for details

Quality Control

Our 3',5'-Dichlorofolic Acid is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting research-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.