Description

Nabumetone CAS NO 42924-53-8 is a non-steroidal anti-inflammatory drug (NSAID) belonging to the arylalkanoic acid class, specifically a naphthylalkanone derivative. It is valued for its prodrug mechanism, which is metabolized in the liver to the active 6-methoxy-2-naphthylacetic acid (6-MNA), potentially offering a favorable gastrointestinal tolerability profile. This compound is primarily required by pharmaceutical manufacturers and research institutions for the formulation of prescription medications targeting pain and inflammation associated with conditions like osteoarthritis and rheumatoid arthritis.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of solid oral dosage forms (e.g., tablets, capsules) for analgesic and anti-inflammatory therapies.
• Generic Drug Production: Sourcing for the development and commercial-scale production of generic nabumetone medications.
• Clinical Research: Utilization as a reference standard or active component in preclinical and clinical studies investigating NSAID efficacy and safety profiles.
• Formulation Development: Serves as a key component in R&D for developing new drug delivery systems or combination therapies.
• Analytical Standard: Used as a high-purity standard in quality control laboratories for HPLC, UV, or other spectroscopic assay methods.

Basic Information

Product Name	Nabumetone
CAS No.	42924-53-8
Molecular Formula	C15H16O2
Molecular Weight	228.29 g/mol
Synonyms	4-(6-Methoxy-2-naphthyl)butan-2-one; Nabumeton; Nabumetona; Nabumetone; Nabumetonum; Relafen; Relifex; Arthaxan; B 381; BRL 14777; CP 16171; Nabuser; Consolan
EINECS	256-001-8

Quality Control

Our Nabumetone is manufactured and tested under a strict quality management system. We ensure compliance with major pharmacopoeial standards, including USP and EP monographs where applicable. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Solubility	Practically insoluble in water; freely soluble in acetone, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.