Description

(3-Trimethylsilyl-2-Propynyl)Triphenylphosphonium Bromide is a specialized organosilicon phosphonium salt, a key reagent in advanced organic synthesis. Its primary value lies in its role as a versatile ylide precursor for the synthesis of complex alkynes and allenes via Wittig-type reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for constructing propargylic and allenyl moieties found in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Research: Used in the development of novel pesticides and herbicides that incorporate silicon-containing alkyne functional groups for enhanced properties.
• Material Science: Serves as a precursor for silicon-acetylene polymers and advanced monomers used in specialty coatings and electronic materials.
• Organic Methodology Development: A valuable tool for chemists developing new catalytic cycles and carbon-carbon bond-forming reactions involving silylated alkynes.
• Natural Product Synthesis: Employed in the stereoselective synthesis of complex natural products containing challenging alkyne segments.
• Ligand and Catalyst Preparation: Used to synthesize phosphine-based ligands with tailored steric and electronic properties for homogeneous catalysis.

Basic Information

Product Name	(3-Trimethylsilyl-2-Propynyl)Triphenylphosphonium Bromide
CAS No.	42134-49-6
Molecular Formula	C24H28BrPSi
Molecular Weight	455.45 g/mol
Synonyms	Triphenyl[(3-trimethylsilyl)prop-2-yn-1-yl]phosphonium bromide; (3-Trimethylsilylprop-2-ynyl)triphenylphosphonium bromide; (Trimethylsilylpropargyl)triphenylphosphonium bromide; Propargyltrimethylsilane triphenylphosphonium bromide; TMS-Propargyl triphenylphosphonium bromide; Phosphonium, [(3-trimethylsilyl)-2-propynyl]triphenyl-, bromide; 42134-49-6
EINECS	Contact for details

Quality Control

Our (3-Trimethylsilyl-2-Propynyl)Triphenylphosphonium Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.