Description

(S)-1-(4-Fluorophenyl)-4-(3,4,6,7,12,12A-Hexahydropyrazino[1',2':1,6]Pyrido[3,4-B]Indol-2(1H)-Yl)Butan-1-One is a high-purity, chiral pharmaceutical intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a key building block in the development of complex, biologically active molecules, particularly within the central nervous system (CNS) therapeutic area. Pharmaceutical R&D teams and fine chemical manufacturers need this material for the synthesis of potential drug candidates, where its defined stereochemistry and structural complexity are critical for achieving desired pharmacological profiles.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the research and development of novel therapeutic agents, particularly in neuroscience and neuropsychiatry.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex APIs targeting specific receptor systems.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Preclinical Development: Employed in the production of compounds for pharmacological evaluation, toxicology studies, and formulation development.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) specializing in custom synthesis for the pharmaceutical industry.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Item	Detail
Product Name	(S)-1-(4-Fluorophenyl)-4-(3,4,6,7,12,12A-Hexahydropyrazino[1',2':1,6]Pyrido[3,4-B]Indol-2(1H)-Yl)Butan-1-One
CAS No.	42021-35-2
Molecular Formula	C25H26FN3O
Molecular Weight	403.50 g/mol
Synonyms	(S)-1-(4-Fluorophenyl)-4-(1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)butan-1-one; (S)-1-(4-Fluorophenyl)-4-(octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)butan-1-one; (S)-1-(p-Fluorophenyl)-4-(1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)butan-1-one; (S)-1-(4-Fluorophenyl)-4-(1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-1-butanone; CAS 42021-35-2
EINECS	Contact for details

Quality Control

Our (S)-1-(4-Fluorophenyl)-4-(3,4,6,7,12,12A-Hexahydropyrazino[1',2':1,6]Pyrido[3,4-B]Indol-2(1H)-Yl)Butan-1-One is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for pharmaceutical R&D applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request for every batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.