Description

Sodium 5-Fluoro-2-Methyl-1-[[4-(Methylsulphinyl)Phenyl]Methylene]-1H-Indene-3-Acetate is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate with significant pharmacological activity. This compound is valued for its role as a key synthetic precursor in the development of advanced pharmaceutical agents targeting inflammation and pain. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel COX-2 inhibitors and other therapeutic molecules.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of selective COX-2 inhibitor drugs, such as etoricoxib analogues.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new anti-inflammatory agents.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a building block in the multi-step synthesis of complex NSAID active ingredients under cGMP conditions.
• Biochemical Research: Employed as a tool compound in pharmacological assays to study prostaglandin pathways and enzyme inhibition.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Sodium 5-Fluoro-2-Methyl-1-[[4-(Methylsulphinyl)Phenyl]Methylene]-1H-Indene-3-Acetate
CAS No.	40796-29-0
Molecular Formula	C20H16FNaO3S
Molecular Weight	378.39 g/mol
Synonyms	5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid sodium salt; Sodium Etoricoxib Intermediate; L-748,780 sodium salt; MK-0663 intermediate; 1-[[4-(Methylsulfinyl)phenyl]methylene]-5-fluoro-2-methyl-1H-indene-3-acetic acid sodium salt; (5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-inden-3-yl)acetic acid sodium salt; Arcoxia intermediate sodium salt.
EINECS	Contact for details

Quality Control

Our Sodium 5-Fluoro-2-Methyl-1-[[4-(Methylsulphinyl)Phenyl]Methylene]-1H-Indene-3-Acetate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines, and our quality commitment supports development work towards cGMP standards for API production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in the original sealed container to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.