Description

Mono-Methyl Polyethylene Glycol 5,000 Glycidyl Ether is a reactive, functionalized PEG derivative designed for advanced material synthesis. This bifunctional molecule is critical for creating stable, covalent linkages between polymers and other substrates, enhancing biocompatibility and modifying surface properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biomedical, and specialty polymer industries for applications such as bioconjugation, hydrogel formation, and surface PEGylation.

Application

• Bioconjugation and Protein Modification: Used to covalently attach polyethylene glycol (PEG) chains to therapeutic proteins and peptides, improving their solubility, stability, and circulation half-life.
• Hydrogel and Biomaterial Synthesis: Serves as a cross-linking agent or functional monomer in the creation of biocompatible hydrogels for drug delivery systems and tissue engineering scaffolds.
• Surface PEGylation: Applied to modify the surface of nanoparticles, medical devices, and diagnostic tools to reduce non-specific protein adsorption and improve biocompatibility.
• Polymer Functionalization: Acts as a macro-initiator or terminating agent to introduce reactive epoxide groups into polymer chains for further chemical modification.
• Chromatography Media: Employed in the functionalization of stationary phases for affinity chromatography and other bioseparation techniques.
• Diagnostic Reagent Preparation: Utilized in the development of diagnostic assays and imaging agents where stable, hydrophilic linkers are required.

Basic Information

Product Name	Mono-Methyl Polyethylene Glycol 5,000 Glycidyl Ether
CAS No.	40349-67-5
Molecular Formula	C2n+5H4n+10On+3 (n ~ 113)
Molecular Weight	~5,000 g/mol (Average Mn)
Synonyms	mPEG-Glycidyl Ether 5000; Methoxy PEG Epoxide 5000; Poly(ethylene glycol) methyl ether glycidyl ether (MW 5000); mPEG-EP 5000; 2-[2-(2-Methoxyethoxy)ethoxy]ethyl glycidyl ether (oligomer); α-Methyl-ω-glycidylpoly(oxy-1,2-ethanediyl); Epoxide-terminated mPEG; Glycidyl ether of monomethoxypolyethylene glycol 5000
EINECS	Contact for details

Quality Control

Our Mono-Methyl Polyethylene Glycol 5,000 Glycidyl Ether is manufactured under a strict quality management system. Each batch is characterized to ensure consistent molecular weight, functionality, and purity. Certificates of Analysis (COA) are provided, detailing key parameters such as assay, epoxide content, polydispersity index (PDI), and residual solvent levels. We support compliance with relevant guidelines for pharmaceutical and biomedical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Under recommended storage conditions, the product is stable for at least 24 months from the date of manufacture. For long-term storage under inert atmosphere, please contact us.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Average Molecular Weight (Mn)	5,000 ± 500
Polydispersity Index (PDI)	≤ 1.10
Assay (Epoxide Content)	≥ 90%
Water Content (KF)	≤ 1.0%
Residual Solvent (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.