Description

Methylmalonic Acid Di(Trimethylsilyl) Ester is a key organosilicon derivative used primarily as a versatile synthetic intermediate and derivatization agent. This compound is particularly valuable for its role in analytical chemistry, where it facilitates the gas chromatographic analysis of complex organic acids by enhancing their volatility and thermal stability. It is an essential reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for synthesis or precise analytical standards.

Application

• GC-MS Derivatization Agent: Critical for the analysis of carboxylic acids, including metabolic profiling in clinical and biomedical research.
• Pharmaceutical Intermediate: Used in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Protecting Group in Organic Synthesis: Serves to protect carboxylic acid functionalities during multi-step synthetic sequences.
• Metabolomics Research: Enables accurate quantification of methylmalonic acid and related metabolites in biological samples.
• Agrochemical Synthesis: Acts as a building block for creating specialized pesticides and herbicides.
• Material Science Precursor: Utilized in the development of silicon-containing polymers and advanced coatings.

Basic Information

Product Name	Methylmalonic Acid Di(Trimethylsilyl) Ester
CAS No.	40333-07-1
Molecular Formula	C11H26O4Si2
Molecular Weight	278.50 g/mol
Synonyms	Bis(trimethylsilyl) methylmalonate; Methylmalonic Acid Bis(trimethylsilyl) Ester; Trimethylsilyl methylmalonate; 2-Methylpropanedioic Acid Di(Trimethylsilyl) Ester; Di(trimethylsilyl) 2-methylmalonate; Methylmalonic Acid Di-TMS Ester; TMS Methylmalonate; 40333-07-1
EINECS	Contact for details

Quality Control

Our Methylmalonic Acid Di(Trimethylsilyl) Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for research and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.