Description

1-Palmitoyl-2-Oleoylglycero-3-Phosphoserine is a high-purity, synthetic phospholipid essential for advanced research and formulation development. This compound serves as a critical building block for creating biomimetic membranes and liposomal delivery systems, offering precise control over lipid bilayer properties. It is primarily utilized by pharmaceutical researchers, cosmetic formulators, and life science companies working on drug delivery, cell biology models, and high-performance skincare applications.

Application

• Liposome & Nanoparticle Formulation: A key component for constructing stable, unilamellar vesicles for targeted drug and gene delivery systems.
• Biomembrane Research: Used to create model lipid bilayers and liposomes for studying membrane protein interactions, permeability, and cell signaling pathways.
• Cosmetic & Dermal Science: Incorporated into advanced skincare formulations such as nanosomes and ethosomes to enhance the penetration and stability of active ingredients.
• Diagnostic Reagents: Serves as a substrate or membrane component in diagnostic kits and assays, including those for phospholipase activity.
• Biophysical Studies: Employed in surface chemistry experiments, including Langmuir-Blodgett film deposition and calorimetry studies to understand lipid packing and phase behavior.
• Cell Culture & Media Supplements: Used as a defined lipid supplement in serum-free cell culture media to support specific cell lines.

Basic Information

Product Name	1-Palmitoyl-2-Oleoylglycero-3-Phosphoserine
CAS No.	40290-44-6
Molecular Formula	C40H76NO10P
Molecular Weight	762.01 g/mol
Synonyms	POPS; 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine; (3-sn-Phosphatidyl)serine (16:0-18:1); PS(16:0/18:1); L-α-Phosphatidylserine (Palmitoyl-Oleoyl); 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoserine; Phosphatidylserine (PO); sn-3-O-(Phosphatidyl)-L-serine
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-Oleoylglycero-3-Phosphoserine is manufactured under strict quality systems. Each batch is characterized and tested to ensure high chemical purity and structural integrity, with comprehensive analysis including HPLC for assay and related substances. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Solvent Residue (GC)	Meets ICH guidelines
Fatty Acid Composition (GC)	Conforms (C16:0, C18:1)
Phosphorus Content	Conforms to theoretical value

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.