Description

Tetrahydro-2H-Pyran-4-Carbonyl Chloride is a versatile and highly reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to efficiently introduce the tetrahydro-2H-pyran-4-carbonyl moiety, a key structural feature in pharmaceuticals and agrochemicals. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity, reliable starting materials for complex molecule construction.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing piperidine or tetrahydropyran analogs.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that incorporate heterocyclic scaffolds.
• Peptide Mimetics & PROTACs: Employed in medicinal chemistry for creating peptide-like structures and proteolysis-targeting chimeras (PROTACs).
• Ligand & Catalyst Development: Serves as a precursor for ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Chemistry: Acts as a monomer or modifying agent for specialty polymers with specific functional properties.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D exploring new synthetic methodologies and novel compound libraries.

Basic Information

Item	Detail
Product Name	Tetrahydro-2H-Pyran-4-Carbonyl Chloride
CAS No.	40191-32-0
Molecular Formula	C6H9ClO2
Molecular Weight	148.59 g/mol
Synonyms	4-(Chlorocarbonyl)tetrahydro-2H-pyran; Tetrahydro-2H-pyran-4-carboxylic acid chloride; Oxane-4-carbonyl chloride; 4-Piperidinecarbonyl chloride, tetrahydro-; Tetrahydropyran-4-carbonyl chloride; THP-4-COCl; 4-Carboxytetrahydropyran chloride
EINECS	Contact for details

Quality Control

Our Tetrahydro-2H-Pyran-4-Carbonyl Chloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay (by GC/HPLC), identity confirmation (IR, NMR), and impurity profiling, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.