Description

3-Amino-6-(Chloromethyl)-2-Pyrazinecarbonitrile 4-Oxide is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring an amino group, a reactive chloromethyl handle, a nitrile, and an N-oxide, makes it a versatile precursor for constructing complex nitrogen-containing scaffolds. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antibacterial agents, and other nitrogen-rich heterocyclic therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its structural motifs can contribute to new modes of action.
• Chemical Research & Development: Serves as a versatile building block for constructing complex pyrazine, pyrazinone, and fused heterocyclic systems in academic and industrial R&D settings.
• Material Science Precursor: Potential use in the synthesis of specialized ligands for catalysis or functional materials due to its multiple coordination and reactive sites.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring tailored, high-purity nitrogen heterocycles.

Basic Information

Product Name	3-Amino-6-(Chloromethyl)-2-Pyrazinecarbonitrile 4-Oxide
CAS No.	40127-89-7
Molecular Formula	C6H5ClN4O
Molecular Weight	184.58 g/mol
Synonyms	2-Pyrazinecarbonitrile, 3-amino-6-(chloromethyl)-, 4-oxide; 3-Amino-6-chloromethyl-2-pyrazinecarbonitrile 1,4-Dioxide; 3-Amino-6-(chloromethyl)pyrazine-2-carbonitrile 4-Oxide; 6-(Chloromethyl)-3-amino-2-pyrazinecarbonitrile 4-Oxide; 3-Amino-6-(chloromethyl)-2-cyanopyrazine 1-Oxide; 3-Amino-6-(chloromethyl)pyrazine 1-oxide-2-carbonitrile
EINECS	Contact for details

Quality Control

Our 3-Amino-6-(Chloromethyl)-2-Pyrazinecarbonitrile 4-Oxide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and production applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable and can provide material to meet specific customer requirements for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.