Description

24(R), 25-Dihydroxyvitamin D3 is a biologically active metabolite of vitamin D3, playing a crucial role in calcium homeostasis and bone metabolism. This high-purity compound is essential for advanced pharmaceutical research and the development of targeted therapeutic agents. It is primarily utilized by researchers and manufacturers in the pharmaceutical, nutraceutical, and life science industries for its specific regulatory functions.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method validation in drug development.
• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic precursor in the manufacture of advanced vitamin D analogs and related therapeutics.
• Biochemical Research: Critical for in-vitro and in-vivo studies investigating the non-classical actions of vitamin D, including cell differentiation, immune modulation, and endocrine functions.
• Metabolic Pathway Studies: Employed to elucidate the complex CYP24A1-mediated catabolic pathway of vitamin D3 and its physiological implications.
• Diagnostic Kit Development: Used in the calibration and development of immunoassays and LC-MS/MS kits for accurate quantification of vitamin D metabolites in clinical samples.
• Nutraceutical Formulation Research: Investigated for potential applications in specialized dietary supplements targeting bone and metabolic health.

Basic Information

Product Name	24(R), 25-Dihydroxyvitamin D3
CAS No.	40013-87-4
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.64 g/mol
Synonyms	(24R)-24,25-Dihydroxycholecalciferol; (24R)-24,25-Dihydroxyvitamin D3; 24R,25-Dihydroxyvitamin D3; 24R,25-(OH)₂D₃; 24R,25-Dihydroxycholecalciferol; 24R,25-Dihydroxycolecalciferol; (5Z,7E)-(1S,3R,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24,25-tetrol
EINECS	Contact for details

Quality Control

Our 24(R), 25-Dihydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified purity grades.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep desiccated to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Specific Optical Rotation	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.