Description

2,3-Dichloropyrazine is a versatile halogenated heterocyclic building block essential for advanced organic synthesis. Its high reactivity, particularly at the chlorine-substituted positions, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, including kinase inhibitors and other biologically active heterocycles.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: Used to prepare functionalized pyrazine derivatives that serve as ligands in catalytic systems or metal-organic frameworks (MOFs).
• Material Science: Intermediate for the production of specialty polymers, dyes, and electronic materials requiring specific heterocyclic components.
• Cross-Coupling Reactions: Serves as an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to introduce the pyrazine moiety.
• Nucleophilic Substitution: The chlorine atoms are readily displaced by various nucleophiles (amines, alkoxides) to create diverse 2,3-disubstituted pyrazine libraries.

Basic Information

Product Name	2,3-Dichloropyrazine
CAS No.	4858-85-9
Molecular Formula	C4H2Cl2N2
Molecular Weight	148.98 g/mol
Synonyms	2,3-Dichloropyrazine; Pyrazine, 2,3-dichloro-; 2,3-Dichloro-1,4-diazine; 2,3-Dichloropyrazine (principal name); Dichloropyrazine; NSC 404083; 4858-85-9
EINECS	225-477-9

Quality Control

Our 2,3-Dichloropyrazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for fine chemical synthesis. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, and impurity profiles is provided with each shipment to guarantee reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	64 - 68 °C
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.