Description

2,6-Dichloropyrazine is a versatile halogenated heterocyclic building block essential for advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules in pharmaceutical and agrochemical research, enabling the introduction of the pyrazine core with reactive chlorine handles. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs containing pyrazine or aminopyrazine moieties.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where the dichloropyrazine structure serves as a core scaffold.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized nitrogen-containing ligands used in catalysis and material science.
• Functional Material Development: Employed in the research and production of electronic materials, dyes, and photoactive compounds.
• Cross-Coupling Reactions: The chlorine atoms are reactive sites for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form carbon-carbon and carbon-heteroatom bonds.
• Nucleophilic Substitution: Acts as a substrate for displacement reactions with various nucleophiles (amines, alkoxides) to generate diverse 2,6-disubstituted pyrazine derivatives.

Basic Information

Product Name	2,6-Dichloropyrazine
CAS No.	4774-14-5
Molecular Formula	C4H2Cl2N2
Molecular Weight	148.98 g/mol
Synonyms	2,6-Dichloro-1,4-diazine; Pyrazine, 2,6-dichloro-; 2,6-Dichloropyrazine; 2,6-Dichloro-1,4-diazabenzene; NSC 5235; 1,4-Diazine, 2,6-dichloro-; Dichloropyrazine
EINECS	Contact for details

Quality Control

Our 2,6-Dichloropyrazine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Related Substances (HPLC)	Individual impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.