Description

Ho-Peg16-Oh CAS NO 4669-05-0 is a high-purity, monodisperse polyethylene glycol (PEG) derivative featuring a hydroxyl group at one terminus, making it a versatile hydrophilic spacer and linker. This compound is critical for creating stable, biocompatible conjugates in advanced pharmaceutical and biotech applications. It is primarily needed by researchers and manufacturers in drug delivery, bioconjugation, and materials science for modifying surfaces, proteins, and nanoparticles to enhance solubility and reduce immunogenicity.

Application

• Pharmaceutical Linker: Used as a spacer in antibody-drug conjugates (ADCs) and peptide-drug conjugates to improve pharmacokinetics and therapeutic index.
• Bioconjugation: Functionalization of proteins, peptides, and enzymes to increase solubility, stability, and circulation time in vivo.
• Nanoparticle Surface Modification: PEGylation of liposomes, polymeric nanoparticles, and quantum dots to impart stealth properties and reduce opsonization.
• Hydrogel Synthesis: Serves as a building block or cross-linker in the development of biocompatible hydrogels for tissue engineering and controlled release.
• Diagnostic Reagents: Modification of contrast agents and fluorescent probes to enhance biocompatibility and targeting specificity.
• Surface Chemistry: Crafting non-fouling, hydrophilic monolayers on biosensors and medical devices to prevent non-specific protein adsorption.

Basic Information

Product Name	Ho-Peg16-Oh CAS NO 4669-05-0
CAS No.	4669-05-0
Molecular Formula	C32H66O17
Molecular Weight	722.86 g/mol
Synonyms	16-Hydroxy-3,6,9,12,15-pentaoxaheptacosan-1-ol; Hexaethylene glycol monomethyl ether; α-Methyl-ω-hydroxy-hexaethylene glycol; mPEG6-OH; PEG6 monomethyl ether; 2-[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol; 3,6,9,12,15-Pentaoxaheptacosane-1,27-diol (methyl derivative); HO-PEG16-CH3
EINECS	Contact for details

Quality Control

Our Ho-Peg16-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and cGMP manufacturing. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight (GPC/SEC)	700 - 750 g/mol
Polydispersity Index (PDI)	≤ 1.05
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.